张爱华
发布时间:2017-10-15 浏览次数:
 

  

张爱华,男,副教授,研究生学历,博士学位

(Email:ahz@hhu.edu.cn)


 

简历

学习经历:

2003年9月至2007年6月     南京林业大学           本科/学士学位

2007年9月至2012年9月     南京大学生命科学学院      研究生/博士学位 


工作经历:

2012年9月至2014年9月     南京大学生命科学学院      博士后

2014年10月至2017年8月    南京大学生命科学学院      科研助理

2017年9月 至今         河海大学海洋学院         副教授 

  


 

研究方向:

海洋来源天然产物的发现及生物功能研究(天然药源/保健品/化妆品)、仿生合成、化合物结构修饰与改造等 

  


 

主讲课程:

《生物化学》 《海洋天然产物与海洋药物》

 


 

科研项目:

国家自然科学基金青年科学基金项目,21402090,2015.1-2017.12,主持

国家自然科学基金重点项目,81530089,2016.1-2020.12,参与

国家自然科学基金重点项目,21132004,2012.1-2016.12,参与   

 


 

论文论著:

1. A. H. Zhang, W. Liu, N. Jiang, X. L. Wang, G. Wang, Q. Xu, and R. X. Tan*. Sequestration of Guest Intermediates by Dalesconol Bioassembly Lines in Daldinia eschscholzii. Org. Lett. 2017, 19, 2142–2145.

IF = 6.732


2. A. H. Zhang, W. Liu, N. Jiang, Q. Xu, and R. X. Tan*. Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor. Org. Lett. 2016, 18, 6496–6499.

IF = 6.732

 

3. A. H. Zhang,  R. Tan, N. Jiang, K. Yusupu, G. Wang, X. L. Wang, and R. X. Tan*. Selesconol, a Fungal Polyketide That Induces Stem Cell Differentiation. Org. Lett. 2016, 18, 5488–5491.

IF = 6.732


4. H. Zhou, X. Z. Deng, A. H. Zhang* 【通讯】 and R. X. Tan*. Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction. Org. Biomol. Chem. 2016, 14, 10407–10414.

IF = 3.559


5. X. Q. Wang, X. F. Wu, A. H. Zhang 【共同一作】, S. Y. Wang, C. H. Hu, W. Chen, Y. Shen, R. X. Tan*, Y. Sun*, Q. Xu*. Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis. EBioMedicine. 2016, 7, 146–156.

 

6. X. Q. Wang, A. H. Zhang 【共同一作】, J. Gao, W. Chen, S. Y. Wang, X. F. Wu, Y. Shen, Y. H. Ke, Z. C. Hua, R. X. Tan*, Y. Sun*, Q. Xu*. Trichomides A, a Natural Cyclodepsipeptide, Exerts Immunosuppressive Activity Against Activated T Lymphocytes by Upregulating SHP2 Activation to Overcome Contact Dermatitis. J. Invest. Dermatol. 2014, 2737–2746.

IF = 6.915

 

7. A. H. Zhang, X. Q. Wang, W. B. Han, Y. Sun, Y. Guo, Qi. Wu, H. M. Ge, Y. C. Song, S. W. Ng, Q. Xu*, R. X. Tan*. Discovery of a New Class of Immunosuppressants from Trichothecium roseum Co-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif. Chem. Asian J. 2013, 8, 3101–3107.

IF = 4.592


8. A. H. Zhang, N. Jiang, W. Gu, J. Ma, Y. R. Wang, Y. C. Song, R. X. Tan*. Characterization, Synthesis and Self-Aggregation of ()-Alternarlactam: A New Fungal Cytotoxin with Cyclopentenone and Isoquinolinone Scaffolds. Chem. Eur. J. 2010, 16, 14479–14485.

IF = 5.771


9. 张爱华,谭仁祥。电子圆二色谱技术在天然产物绝对构型确定中的应用。国际药学研究杂志。2015,


10. Wen Bo Han, Ai Hua Zhang, Xin Zhao Deng, Xinxiang Lei, Ren Xiang Tan*. Curindolizine, an Anti-Inflammatory Agent Assembled via Michael Addition of Pyrrole Alkaloids Inside Fungal Cells. Org. Lett. 2016, 18, 18161819.

 

11. Yuan Tian, Nan Jiang, Ai Hua Zhang, Chao Jun Chen, Xin Zhao Deng, Wen Jing Zhang, Ren Xiang Tan*. Muta-mycosynthesis of naphthalene analogs. Org. Lett. 2015, 17, 1457–1460. 

  

12. Ya Nan Song, Rui Hua Jiao, Wen Jing Zhang, Guo Yan Zhao, Huan Dou, Rong Jiang, Ai Hua Zhang, Ya Yi Hou, Shu Feng Bi, Hui Ming Ge*, Ren Xiang Tan*. New ansamycin derivatives generated by simultaneous mutasynthesis. Org. Lett. 2015, 17, 556–559.

 

13. W. B. Han, Y. H. Lu, A. H. Zhang, G. F. Zhang, Y. N. Mei, N. Jiang,  X. X. Lei, Y. C. Song, S. W, R. X. Tan*. Curvulamine, a new antibacterial alkaloid incorporating two undescribed units from a Curvularia species. Org. Lett. 2014, 16, 5366–5369. 

 

14. W. Fang, S. Ji, N. Jiang, W. Wang, G. Y. Zhao, S. Zhang, H. M. Ge, Q. Xu, A. H. Zhang, Y. L. Zhang, Y. C. Song, J. Zhang, R. X. Tan*. Naphthol radical couplings determine structural features and enantiomeric excess of dalesconols in Daldinia eschscholzii. Nat. Commun. 2012, 3, 1039.

 

15. R. H. Du, J. T. Cui, T. Wang, A. H. Zhang, R. X. Tan*. Trichothecin induces apoptosis of HepG2 cells via caspase-9 mediated activation of the mitochondrial death pathway. Toxicon 2012, 59, 143–150. 

 

 


 

表彰奖励:

优秀研究生奖南京大学, 2010

真知味奖学金南京大学, 2010 

 


 

学术兼职