张爱华

发布时间:2017-12-31浏览次数:25646

张爱华,男,副教授

(Email:ahz@hhu.edu.cn,电话/微信:15050589489)


 

简历

学习经历:

2003年9月至2007年6月     南京林业大学            本科/学士学位

2007年9月至2012年9月     南京大学               研究生/博士学位 


工作经历:

2012年9月至2014年9月     南京大学               博士后

2014年10月至2017年8月    南京大学               副研究员

2017年9月 至今         河海大学海洋学院          副教授 

2018年9月至2019年8月     江苏省第十一批科技镇长团     江宁滨江经济开发区管委会副主任

2023年5月 至今    南通河海大学海洋与近海工程研究院  院长

  


 

研究方向:

(1)海洋来源活性物质的发掘及产业推广(生物功能制品/保健品/化妆品);

(2)藻类综合利用,规模化培养工艺、高效浓缩收集装置、生物资源产品开发等

(3)微藻微生态制剂产品、工艺、装备的成果转化与市场推广

  


 

主讲课程:

《生物化学》 《海洋天然产物与海洋药物》

 


 

科研项目:

海洋微藻多糖高效提取及其产品开发(江苏省海洋科技创新项目,JSZRHYKJ202309,31.5万/90万,2023.10-2025.10,主持课题一

微藻服务于“中国农技协江苏高淳虾蟹共作科技小院”,923067616,30万,2023.5-2024.5,主持

微藻资源高效利用高效利用关键技术开发与工程化示范,822153216,206万,2022.10-2023.12,主持

一种用于微藻培养和采收的一体化装置和微藻培养方法,922147716,50万,2022.6-2023.6,主持

光藻渔碳中和一体”示范研发项目,822032016,80万,2022.3-2022.12,主持

新型海藻液高效浓缩分离装置及专有技术,科技成果转化,30万,2021.6-2024.6,主持

国家重点研发计划“蓝色粮仓科技创新”子课题“滩涂藻类产品及生物制品”,521007912,59万,2020.10-2022.12,主持

中央高校基本科研业务费,B17020066,20万,2018.1-2020.12,主持

雨生红球藻培养、虾青素提取技术开发,20万,2019.1-2020.12,主持

国家自然科学基金青年科学基金项目,21402090,25万,2015.1-2017.12,主持

国家自然科学基金重点项目,81530089,2016.1-2020.12,参与

国家自然科学基金重点项目,21132004,2012.1-2016.12,参与

   


 

论文论著:

2024

1. Sanjiong Yi, Ai-Hua Zhang*, Jianke Huang*, Ting Yao, Bo Feng, Xinghu Zhou, Yadong Hu* and Mingxuan Pan. Maximizing Polysaccharides and Phycoerythrin in Porphyridium purpureum via the Addition of Exogenous Compounds: A Response-Surface-Methodology Approach. Mar. Drugs 2024, 22, 138.


2. Ai Hua Zhang, Hao Tang, Lu Wang, Wei He, Tian Heng Gao*, Zhi Gang Gao, Dao-Feng Zhang*. Characterization of Actomonas aquatica Gen.nov.sp.nov.a marine lineage with genetic potentials of carbon and nitrogen corresponding.International Journal of Systematic and Evolutionary Microbiology, 2024, 74:006314.


3. Wei He, Hong-Chuan Wang, Lu Wang, Hua-Peng Xue, Yong-Fu Li, Ai Hua Zhang* and Dao-Feng Zhang*. Ruegeria marisflavi sp. nov. and Ruegeria aquimaris sp. nov., isolated from seawater of the Yellow Sea. International Journal of Systematic and Evolutionary Microbiology, 2024, 74:006323.


4. Yongfu Li, Tianze Zhao, Meng Qin, Xingkai Che*, Aihua Zhang*. Toxicity of the sunscreen UV filter benzophenone-3 (OBZ) to the microalga Selenastrum capricornutum: An insight into OBZ’s damage to photosynthesis and respiration. Ecotoxicology and Environmental Safety, 2024, 116441. 


5. 张爱华,房世豪,郭文洁,刘雯,高天珩. 茚满酮类化合物及其生物素衍生物、制备方法、应用. 专 利 号:ZL 202210485755.X


2023

1. Ai Hua Zhang, Shihao Fang, Huan Xi, Jianke Huang, Yongfu Li, Guangyuan Ma*, Jianfeng Zhang*. Highly efficient and selective removal of phosphate from wastewater of sea cucumber aquaculture for microalgae culture using a new adsorption-membrane separation-coordinated strategy. Frontiers of Environmental Science & Engineering,  2023, 17(9): 120.


2. Ai Hua Zhang, Ziyan Wei, Jingliang Huang*, Chuang Liu*. Shell proteins and microstructural analysis identify the origin of shell arts with species resolution in pearl oysters. Journal of Archaeological Science, 2023, 151, 105729.


3. Lu Wang· Hua‑Peng Xue· Dao‑Feng Zhang*· Jian‑Ke Huang· Chuang Liu· Ai Hua Zhang*. Description of Nocardioides jiangsuensis sp. nov., and Proposal for Reclassification of the Genus Marmoricola as Nocardioides. Current Microbiology, 2023, 80:60.


4. Yanan Deng, Aihua Zhang*, Zheng Zhang, Yidan Xu, Gaiye Li, Montree Hankoy, Mettaya Kitiwan, Shaoyu Wu, Ping Dong, Yang Nan, Weixing Xu, Jianfeng Zhang*. Thin film nanocomposite nanofiltration with tannic acid-Fe(III) complexes functionalized Ti3C2Tx for enhanced divalent-salinity-water separation with a superior durability. Journal of Membrane Science, 2023, 122333.


5. 张爱华,周勇胜,马广源,周兴虎,房世豪,汤皓.  一种智能微藻浓缩采收装置. 授权号:ZL 202320507514.0


2022

1. Wen Liu#, Jiashu Yang#, Shihao Fang#, Chenyang Jiao, Jianhua Gao, Aihua Zhang*, Tiancong Wu*, Renxiang Tan, Qiang Xu, Wenjie Guo*, Spirodalesol analog 8A inhibits NLRP3 inflammasome activation and attenuates inflammatory disease by directly targeting adaptor protein ASC, J Bio Chem. 2022, 298(12):102696.


2. T. Yao, J. Huang*, B. Su, L. Wei, A.-H. Zhang*, D.-F. Zhang, Y. Zhou, G. Ma, Enhanced phycocyanin production of Arthrospira maxima by addition of mineral elements and polypeptides using response surface methodology, Frontiers in Marine Science, 2022, 9:1057201.


3. Lu Wang, Wei He, Zeng‑Yu Gao, Dao‑Feng Zhang, Jian‑Ke Huang, Chuang Liu, Wen‑Jun Li, Ai Hua Zhang*. Hyphomonas sediminis sp. nov., isolated from marine sediment, Antonie van Leeuwenhoek, 2022, 115, 1177–1185.


4. 张爱华,卫子嫣,姚宇阗,张道锋,黄建科,刘闯. 东风螺、弯竹蛏和斑节对虾的壳基质蛋白组学分析,海岸工程,2022, 41(3), 258-267.


5. 张爱华,成守斌,易三炯. 管道和薄层自流式光生物反应器耦合的微藻培养系统,授权号:ZL  202220660145.4


6. Ai Hua Zhang, Bo Feng, Han Zhang, Jinshun Jiang, Daofeng Zhang, Yi Du, Zheng Cheng, Jianke Huang. Efcient cultivation of Porphyridium purpureum integrated with swine wastewater treatment to produce phycoerythrin and polysaccharide. Journal of Applied Phycology, 2022, 34, 2315–2326.


7. Zeng‑Yu Gao,  Hua‑Peng Xue, Lu Wang, Yutian Yao, Dao‑Feng Zhang, Jianke Huang*, Chuang Liu, Ai Hua Zhang*. Sphingopyxis jiangsuensis sp. nov. Isolated From the Surface Water of the Yellow Sea. Current Microbiology, 2022, 79:214.


8. 张爱华,房世豪,李敬霖,刘玲,戴思远,方铭琛,马金戈. 微藻液高效浓缩收集装置,授权号:ZL 202122269237.8


9. 张爱华,房世豪,黄建科,吴成松. 一种具有保健效果的紫菜藻片的制备方法,授权号:ZL 202010978256.5


10. 黄建科,张爱华,用于微藻兼性生长模式培养的生物反应器及其工作方法,授权号:ZL 201911118818.2


11. 黄建科,江金顺,张爱华,范江鹏,姚婷,秦萌,王灿,徐雪峰,廖静. 一种耦合糠醛废水处理与微藻培养的方法,授权号:ZL 202011421535.8


2021之前

1. H. Xi, H. Jiang, D. Zhao, A. H. Zhang*, B. Fan, Y. Yang, J. Zhang*. Highly selective adsorption of phosphate from high-salinity water environment using MgO-loaded and sodium alginate-immobilized bentonite beads. Journal of Cleaner Production 2021, 313, 127773.

IF = 11.072


2. D. F. Zhang, X. W. Cui, W. J. Li, X. M. Zhang, H. P. Xue, J. K. Huang, A. H. Zhang*. Description of Salinimonas profundi sp. nov., a deep-sea bacterium harboring a transposon Tn6333. Antonie van Leeuwenhoek 2021, 114, 69–81.

IF = 2.271


3. 张爱华,张道锋,构建原核生物核心基因进化树软件EasyCGTreeV1.0,软件著作权,2020SR1502387.


4. H. Zhang, Z. Wei, A. H. Zhang*, and S. Yu*. Access to Cyanoimines Enabled by Dual Photoredox/Copper-Catalyzed Cyanation of O-Acyl Oximes. Org. Lett. 2020, 22, 73157320.

IF = 6.555


5. A. H. Zhang, N. Jiang, X. Q. Wang, and R. X. Tan*. Galewone, an Anti-Fibrotic Polyketide from Daldinia eschscholzii with an Undescribed Carbon Skeleton. Sci. Rep. 2019, 9, 14316.

IF = 4.996


6. A. H. Zhang, W. Liu, N. Jiang, X. L. Wang, G. Wang, Q. Xu, and R. X. Tan*. Sequestration of Guest Intermediates by Dalesconol Bioassembly Lines in Daldinia eschscholzii. Org. Lett. 2017, 19, 2142–2145.

IF = 6.732


7. A. H. Zhang, W. Liu, N. Jiang, Q. Xu, and R. X. Tan*. Spirodalesol, an NLRP3 Inflammasome Activation Inhibitor. Org. Lett. 2016, 18, 6496–6499.

IF = 6.732

 

8. A. H. Zhang,  R. Tan, N. Jiang, K. Yusupu, G. Wang, X. L. Wang, and R. X. Tan*. Selesconol, a Fungal Polyketide That Induces Stem Cell Differentiation. Org. Lett. 2016, 18, 5488–5491.

IF = 6.732


9. H. Zhou, X. Z. Deng, A. H. Zhang* 【通讯】 and R. X. Tan*. Visible-light-promoted synthesis of phenanthridines via an intermolecular isocyanide insertion reaction. Org. Biomol. Chem. 2016, 14, 10407–10414.

IF = 3.559


10. X. Q. Wang, X. F. Wu, A. H. Zhang 【共同一作】, S. Y. Wang, C. H. Hu, W. Chen, Y. Shen, R. X. Tan*, Y. Sun*, Q. Xu*. Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis. EBioMedicine 2016, 7, 146–156.

IF = 6.183

 

11. X. Q. Wang, A. H. Zhang 【共同一作】, J. Gao, W. Chen, S. Y. Wang, X. F. Wu, Y. Shen, Y. H. Ke, Z. C. Hua, R. X. Tan*, Y. Sun*, Q. Xu*. Trichomides A, a Natural Cyclodepsipeptide, Exerts Immunosuppressive Activity Against Activated T Lymphocytes by Upregulating SHP2 Activation to Overcome Contact Dermatitis. J. Invest. Dermatol. 2014, 2737–2746.

IF = 8.551

 

12. A. H. Zhang, X. Q. Wang, W. B. Han, Y. Sun, Y. Guo, Qi. Wu, H. M. Ge, Y. C. Song, S. W. Ng, Q. Xu*, R. X. Tan*. Discovery of a New Class of Immunosuppressants from Trichothecium roseum Co-inspired by Cross-Kingdom Similarity in Innate Immunity and Pharmacophore Motif. Chem. Asian J. 2013, 8, 3101–3107.

IF = 4.592


13. A. H. Zhang, N. Jiang, W. Gu, J. Ma, Y. R. Wang, Y. C. Song, R. X. Tan*. Characterization, Synthesis and Self-Aggregation of ()-Alternarlactam: A New Fungal Cytotoxin with Cyclopentenone and Isoquinolinone Scaffolds. Chem. Eur. J. 2010, 16, 14479–14485.

IF = 5.771


14. 张爱华,谭仁祥。电子圆二色谱技术在天然产物绝对构型确定中的应用。国际药学研究杂志。2015.




 

表彰奖励:

2021,微藻液高效浓缩收集装置参加“第十四届全国大学生节能减排社会实践与科技竞赛”获得校赛一等奖、国赛三等奖。

2019,因在科研成果转化方面贡献突出,作为江苏省第十一批科技镇长团团员,挂职江宁滨江经济开发区管委会副主任1年,挂职期满后获“省级优秀团员”、“江苏省科技镇长团荣誉团员”、“江宁区创新发展特聘顾问”。

优秀研究生奖南京大学, 2010

真知味奖学金南京大学, 2010 

 


 

海洋生物资源产品

为高质量按时完成国家重点研发计划“蓝色粮仓科技创新”重点专项“黄渤海滩涂生态农牧化与三产融合模式示范”项目课题“滩涂生态农牧场特色生物资源产品和生物制品及示范”(课题编号:2020YFD0900704),研究开发了“钝顶螺旋藻粉&蛋白核小球藻粉”复合片,体外抗肿瘤活性测试表明:混合片提取物对人结肠癌细胞HCT116的抑制率比单独的钝顶螺旋藻粉、蛋白核小球藻粉提取物分别高出12.7%、8.9%,对肝癌细胞HepG2的抑制率比单独的钝顶螺旋藻粉、蛋白核小球藻粉提取物分别高出17.4%、28.1%。开发了“裸藻&钝顶螺旋藻”复合片,混合片提取物对人结肠癌细胞HCT116的抑制率比单独的钝顶螺旋藻粉、裸藻粉提取物分别高出7.3%、17.2%;对肝癌细胞HepG2的抑制率比单独的钝顶螺旋藻粉、蛋白核小球藻粉提取物分别高出7.3%、24%。两款产品(专利申请号:202210244327.8)已推向市场,并取得了良好的社会评价和经济效益。

微藻大规模培养后,藻液的浓度低、体积大, 给保存、运输和投用带来极大困难,是国家“节能减排”倡导下面临的重大“卡脖子”问题。研制了新型的微藻液高效浓缩分离装置,带领本科生参加“第十四届全国大学生节能减排社会实践与科技竞赛”获得校赛一等奖,国赛三等奖,(作品编号:143238050,作品名称:新型海藻液高效浓缩分离装置)”。对该项目进行了科技成果转化,成果名称:新型海藻液高效浓缩分离装置及专有技术(专利号:202122269237.8),交易价格:30万元。